Afghan officials suggested the latest bombing appeared to be an attempt to derail the burgeoning peace process, vowing that it would not go unanswered.
Although ISIS claimed responsibility, President Ashraf Ghani put part of the blame on the Taliban and on sanctuaries of suicide bombers in neighbouring countries.
A suicide bomb tore through a banquet hall filled with hundreds of religious scholars gathered to mark the Prophet Mohammad's birthday, killing at least 55 people.
Thousands of people abandoned their homes in Hazara-dominated areas in the province the past week, as the Taliban intensified their fighting, killing dozens of innocent civilians.
Through threats of violence and imprisonment, the Taliban militants pressure local farmers to pay ushr and then use the proceeds to fight the Afghan government, locals say.
Seventeen years later, al-Qaeda is still focused on its 'victory' in the September 11 terrorist attacks in the United States, debunking conspiracy theorists -- and proving its loss of relevance.
In one incident, ISIS elements accused a long-time supporter of the group of being a spy and of spreading false news in an attempt to destabilise the group and sow discord among its members.
In one of the attacks, bombs went off in front of two schools for young children in Jalalabad.
ISIS claimed responsibility for the attack, which Afghan officials say killed at least 26 people and wounded 91.
Iran's relationship with al-Qaeda began during the Osama bin Laden era and continued after his death with the hosting of his family.
'We are chasing ISIS,' an Afghan National Army commander said. 'Wherever it rises up, we will kill it.'
A roadside bomb hit a bus in Farah, killing mostly women and children, while gunmen stormed a building in Jalalabad while officials were meeting with foreign aid agencies.